People who have these traits may have difficulty functioning in society. These traits are typically seen as negative or maladaptive, and can include things like impulsivity, aggression, and a lack of empathy. It includes experts in childhood and adult psychiatry and research-intensive SMEs ensuring maximal dissemination, clinical implementation and business development opportunities. Pathological personality traits refer to a set of characteristics that are associated with increased risk for developing mental disorders. The Aggressotype consortium is based on successful existing collaborations. For the identification of novel pharmacological compounds in aggression treatment, we introduce a new animal model, the zebrafish. Pathological Internet Use, Aggression, and Cyberbullying in Children and Adolescents With Attention Deficit Hyperactivity Disorder December 2021 DOI: 10.5152/alphapsychiatry.2021. Further contributions to understanding pathological aggression was provided by studies concentrating on the neurobiological correlates of reactive and proactive aggression in overly aggressive groups. In addition to this approach towards prevention, we test promising non-pharmacological biofeedback for personalised treatment and prevention of overt aggression. Based on innovative bioinformatic multimodal data integration, our interdisciplinary research will lead to novel, accurate algorithms for reliable aggression prediction, which will be validated in existing longitudinal studies in children and tested for their predictive value in adult outcome. This is accompanied by highly powered analyses of the neural substrates of the aggression subtypes. Through this, we build a knowledge chain from molecule to behaviour, investigating known and novel genes, gene-networks and their epigenetic interactions, and mapping their mode of action from the molecular via the cellular to the brain-circuit level. We employ highly innovative approaches in humans and animal models and maximize the output from the project by optimally balancing the use of large, existing data sets with new data acquisition. Contingent to a subdivision into impulsive and instrumental subtypes, we investigate the aetiology of maladaptive aggression in paediatric conduct disorders most strongly predisposing to pathological aggression, ADHD and conduct disorder, and in the general population. This behavior can be part of a personality disorder such as antisocial, narcissistic. They often continue the pattern for years. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Pathological lying usually starts when a person is in their teens. ![]() When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. The regulation of aggression by a wide spectrum of neurotransmitters is well known. However, pathological demand avoidance is all-encompassing and has some unique aspects: many everyday demands are avoided simply because they are demands. Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation.
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